About 30% of people with schizophrenia do not have adequate response to antipsychotic medications other than clozapine. Treatment-resistant psychosis has no well-established predictors although early-onset psychosis and prolonged duration of untreated psychosis may be risk factors. Up to 30% of patients with treatment-resistant schizophrenia treated with clozapine have residual positive symptoms. Clozapine augmentation is a common approach, but the evidence supporting this practice is limited. Methamphetamine-induced psychosis (MIP) in Iran has turned into a serious issue in terms of health and treatment, lacking any obvious treatment methods for its resistant cases. Aims of Case Report. In the present study, a number of two cases of treatment of MIP with clozapine, which were resistant to the treatment with other antipsychotics, have been reported. Treatment resistance or refractory psychosis is psychosis that hasn’t responded to two or more antipsychotic medications. Learn about clozapine, a medication that may help. Treatment-resistant symptoms complicate the clinical course of schizophrenia, and a large proportion of patients do not reach functional recovery. In consequence, polypharmacy is frequently used in treatment-refractory cases, addressing psychotic positive, negative and cognitive symptoms, treatment Off-label prescribing of two or more antipsychotics for treatment-resistant psychosis carries inherent risks for both schizophrenia patients and their psychiatrists. Because clozapine is the treatment of choice for treatment-resistant psychosis, consider tactics that maintain its benefits while reducing its metabolic liabilities. Reducing the clozapine dosage (if feasible) is the first-line approach, but partially substituting another antipsychotic might help if psychotic symptoms return. of clozapine? 6. How is clozapine use monitored and managed? 6. How are medication switches best managed? 8. What are the risks of stopping taking antipsychotic medication? 9. What are some strategies to deal with not wanting to take antipsychotic medication? This resource developed by: Information on clozapine and other options help for treatment resistant psychosis (refractory psychosis. Management of clozapine-resistant schizophrenia - Volume 11 Issue 2 - Rob W. Kerwin, Anusha Bolonna Skip to main content We use cookies to distinguish you from other users and to provide you with a better experience on our websites.